Pindolol-insensitive [3 H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors
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منابع مشابه
5-Hydroxytryptamine inhibits neuronal high-voltage-activated calcium currents in the preoptic anterior hypothalamus via 5-hydroxytryptamine 1A and 7 receptors
5-Hydroxytryptamine (5-HT) is involved in mammalian thermoregulation of the preoptic anterior hypothalamus (PO/AH), but the underlying molecular mechanisms are not fully understood. In this study, we investigated the influence of 5-HT and agonists and antagonists of the 5-HT1A, 5-HT2A, 5-HT3 and 5-HT7 receptors on voltage-gated calcium currents in the PO/AH slice with the whole-cell patch clamp...
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This study was designed to examine the effects of intracerebroventricular (ICV) injection of ketanserin(5-HT2a receptor antagonist) and SB242084 (5-HT2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. In experiment 1, birds were injec...
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In the present study non-5-HT1A/non-5-HT1Q binding sites in the rabbit caudate nucleus (CN) were examined to determine if they might be identical to the recently discoverd 5-HT1D sites in the bovine CN. The characterizations were carried out measuring high-affinity [3H]5-HT binding under conditions where 5-HTja and 5-HTjq sites were pharmacologically masked in both tissues. Comparison of the ph...
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The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT, serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic effects. The acute cardiac effects of 5-HT consist of tachycardia (preceded on occasion by a brief reflex bradycardia), increased atrial contractility and production of atrial arrhythmias. Acute inotropic, lusitropic and arrhythm...
متن کامل5- Hydroxytryptamine
eral kinetic systems and compares their properties (after cautioning the reader of the possible pitfalls and of the assumptions which must be made) with various biological phenomena such as regulation, regeneration, determination , gene action, pleiotropism, etc. Few biologists have been as successful as Waddington in accomplishing a synthesis between embryology and genetics. In this volume, he...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1999
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0702503